Often this comes into the subnetting discussion by my friends who are deploying IPv6 for the first time. How do you calculate subnets outside the 4-bit nibble boundary? This also happens to be one of starting points of APNIC IPv6 routing workshop where I occasionally instruct as community trainer.
So what is a Nibble boundary? In IPv6 context, it refers to 4 bit and any change in multiple of 4 bits is easy to calculate.
One of my friend went for a VM with a German hosting provider. He got single IPv4 (quite common) and a /64 IPv6. Overall /64 per VM/end server used to be ok till few years back but now these days running applications inside LXC containers (OS level virtualization) make more sense. This gives option to maintain separate hosting environment for each application. I personally do that a lot and infect blog which you are reading right now itself is on a LXC container.
Subnetting IPv6 sounds very complex but to be true - it is very easy! All you need to do is to understand basics of IPv6 addressesing - how an address is formed and how to efficiently use CIDR notation. Firstly how an IPv6 address looks like? (good to clear fundamentals first!) An IPv6 address has 8 sections seprated by coloums and each sections has carries 4 hexadecimal digits. So an IPv6 address is something like: xxxx:xxxx:xxxx:xxxx:xxxx:xxxx:xxxx:xxxx - Each x can have a hexa decimal value i.